Invention Grant
US08691982B2 Pyrazolo[1,5-a]-1,3,5-triazine derivatives, preparation thereof, and therapeutic use thereof
有权
吡唑并[1,5-a] -1,3,5-三嗪衍生物及其治疗用途
- Patent Title: Pyrazolo[1,5-a]-1,3,5-triazine derivatives, preparation thereof, and therapeutic use thereof
- Patent Title (中): 吡唑并[1,5-a] -1,3,5-三嗪衍生物及其治疗用途
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Application No.: US13203427Application Date: 2010-03-11
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Publication No.: US08691982B2Publication Date: 2014-04-08
- Inventor: Laurent Meijer , Hervé Galons , Benoit Joseph , Florence Popowycz , Nassima Oumata
- Applicant: Laurent Meijer , Hervé Galons , Benoit Joseph , Florence Popowycz , Nassima Oumata
- Applicant Address: FR Paris FR Paris FR Villeurbanne FR Paris
- Assignee: Centre National de la Recherche Scientifique,Universite Paris Descartes,Universite Claude Bernard Lyon 1,Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee: Centre National de la Recherche Scientifique,Universite Paris Descartes,Universite Claude Bernard Lyon 1,Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee Address: FR Paris FR Paris FR Villeurbanne FR Paris
- Agency: Oliff PLC
- Priority: FR0951521 20090311
- International Application: PCT/IB2010/051063 WO 20100311
- International Announcement: WO2010/103486 WO 20100916
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/53 ; A61P35/00
![Pyrazolo[1,5-a]-1,3,5-triazine derivatives, preparation thereof, and therapeutic use thereof](/abs-image/US/2014/04/08/US08691982B2/abs.jpg.150x150.jpg)
Abstract:
A compound of formula (I), or a pharmaceutically acceptable salt thereof, where R1 is a (C1-C6)alkyl or (C3-C6)cycloalkyl group; R2 is a (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkenyl, (C1-C6)fluoroalkyl, (C1-C3)fluoroalkoxy, or (C1-C6)alkoxy(C1-C6)alkyl group, substituted: (i) with one to three hydroxyl groups, or (ii) with an NRaRb group, where Ra and Rb are independently a hydrogen atom or a (C1-C3)alkyl group; or a pyrrolidinylmethyl group substituted with one to three hydroxyl groups; R9 is the same as R2 or hydrogen; the R2 and R9 groups independently being substitutable with an —OCOR3 group, where R3 is a natural or unnatural amino acid derivative or a piperidyl group; alternatively, R2 and R9 together form a heterocyclic compound; X and Y are independently a substitutable phenyl or heteroaryl group, the heteroaryl group being a thienyl, pyridyl, pyrimidinyl, thiazolyl, pyrrolyl, or furanyl group; and R6 is a hydrogen or a (C1-C3)alkyl group.
Public/Granted literature
- US20120184557A1 PYRAZOLO[1,5-A]-1,3,5-TRIAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF Public/Granted day:2012-07-19
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