A multiplex driving circuit receives m master signals and n slave signals, and includes m driving modules for generating m×n gate driving signals. Each driving module includes a voltage boost stage and n driving stages. The voltage boost stage is used for receiving a first master signal of the m master signals and converting the first master signal into a first high voltage signal, wherein a high logic level of the first master signal is increased to a highest voltage by the voltage boost stage. The n driving stages receives the n slave signals, respectively, and receives the first high voltage signal. In response to the highest voltage of the first high voltage signal, the n driving stages sequentially generates n gate driving signals according to the n slave signals.