A method and device for transmitting and receiving a signal in a wireless communication system. The method for transmitting a signal in a wireless communication system includes: receiving an original data block to be transmitted, the length of the original data block being M, wherein M is an integer; disordering the original data block for one or more times, whereby M data symbols in the original data block are rearranged in each of the one or more times of the disordering, so as to obtain one or more disordered data blocks with length of M; cascading the original data block and the one or more disordered data blocks with a cyclic prefix, to form an equalized signal of frequency domain diversity with time-frequency interleaving; and transmitting the equalized signal of frequency domain diversity through a single carrier.