These various embodiments access target information regarding a radiation-therapy treatment volume for a given patient as well as non-target information regarding at least one structure other than the radiation-therapy treatment volume that also comprises a part of the given patient. These embodiments then provide for accessing uncertainties information regarding spatial uncertainties as pertain to at least one of the target information and the non-target information and using that uncertainties information to characterize at least one radiation-therapy treatment plan optimization consideration with respect to a preference of usage to thereby provide preference considerations. These preference considerations are then used to influence a follow-on radiation-therapy treatment plan optimization process when developing a treatment plan for the radiation-therapy treatment volume.