A method, medium, and apparatus canceling noise from a mixed sound. The method includes receiving sound source signals including a target sound and noise, extracting at least one feature vector indicating an attribute difference between the sound source signals from the sound source signals, calculating a suppression coefficient considering ratios of noise to the sound source signals based on the at least one extracted feature vector, and canceling the sound source signals corresponding to noise by controlling an intensity of an output signal generated from the sound source signals according to the calculated suppression coefficient. Accordingly, a clear target sound source signal can be obtained.