Disclosed are systems and methods for efficient matching for content-based addressing wherein the systems and methods may: accept, at a receiver machine, a query; generate, at the receiver machine, a tree structure ordered by one or more fields of the query; analyze, at the receiver machine, a message from the sender machine; search, by the receiver machine, the tree structure using content from one or more fields of the message; determine, by the receiver machine, if the content values of the message match a content value of the query stored in the tree structure; and accept, by the receiver machine, the message if the content value of the message matches one or more content values of the query.