A system and method in one embodiment includes modules for detecting an access attempt to a critical address space (CAS) of a guest operating system (OS) that has implemented address space layout randomization in a hypervisor environment, identifying a process attempting the access, and taking an action if the process is not permitted to access the CAS. The action can be selected from: reporting the access to a management console of the hypervisor, providing a recommendation to the guest OS, and automatically taking an action within the guest OS. Other embodiments include identifying a machine address corresponding to the CAS by forcing a page fault in the guest OS, resolving a guest physical address from a guest virtual address corresponding to the CAS, and mapping the machine address to the guest physical address.