A mechanism is provided for invoking multi-library application on a multiple processor system, wherein the multiple processor system comprises a Power Processing Element (PPE) and a plurality of Synergistic Processing Element (SPE). Applications including multi-libraries run in the memory of the PPEs. The mechanism comprises maintaining the status of each SPE in the applications running on the PPE, where there are SPE agents for capturing the instructions from the PPE in the SPEs that have been started. In response to a request for invoking a library, the PPE determines whether the number of available SPEs for invoking the library is adequate based on the current status of SPEs. If the number of available SPEs is adequate, the PPE sends a run instruction to selected SPEs. After finishing the invocation of all libraries, the PPE sends termination instructions to all started SPEs.