Exemplary methods and systems for managing an e-reader interface are disclosed herein. An exemplary method includes an e-reader interface management system directing an e-reader device to display a plurality of graphical objects representative of a plurality of segments of an e-publication, detecting a user interaction with a graphical object within the plurality of graphical objects and representative of a segment within the plurality of segments, and directing the e-reader device to remove at least one other graphical object within the graphical objects from the display of the graphical objects, wherein the at least one other graphical object is representative of at least one other segment within the plurality of segments that is unrelated to the segment. Corresponding methods and systems are also disclosed.