An aircraft fuselage structure with frames (11) running transversely with respect to the longitudinal direction of the fuselage, and main deck cross members (14) is disclosed. The aircraft fuselage structure contains premanufactured integral units (10) which each comprise at least the lower region of the fuselage frame (11) and the main deck cross member (14), the fuselage frame (11) and a region (14a) of the main deck cross member (14) that spans at least an essential part of the width of the main deck and merges on both sides into the fuselage frame (11) being premanufactured in the form of an integral component.