The present invention provides a method of manufacturing a pneumatic tire, which can prevent an air pocket from being generated in a vicinity of a spliced portion of a sheet member (B) to be attached to an inner liner, even in the case of using, as the inner liner, a sheet member (A) made of a composition containing a resin component. The method includes a step of laminating a sheet member (A) and a sheet member (B) while being pressed on a making drum. The sheet member (B) is made of a rubber composition, and has two end portions in the circumferential direction overlapped and spliced with each other. In the method, a cut line of each end of the sheet member (B) in the circumferential direction has a vertex in the intermediate point in the width direction of the sheet member (B). Moreover, the cut line is displaced in the opposite direction to the rotational direction of the making drum as extending from the vertex to each of the right and left edges in the width direction.