Invention Grant
US08697069B2 Methods related to TIM 3, a Th1-specific cell surface molecule, for activating antigen presenting cells
有权
与TIM3相关的方法，一种Th1特异性细胞表面分子，用于激活抗原呈递细胞
- Patent Title: Methods related to TIM 3, a Th1-specific cell surface molecule, for activating antigen presenting cells
- Patent Title (中): 与TIM3相关的方法，一种Th1特异性细胞表面分子，用于激活抗原呈递细胞
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Application No.: US13331387Application Date: 2011-12-20
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Publication No.: US08697069B2Publication Date: 2014-04-15
- Inventor: Vijay K. Kuchroo , Laurent Monney , Jason L. Gaglia , Edward A. Greenfield , Gordon J. Freeman , Hanspeter Waldner
- Applicant: Vijay K. Kuchroo , Laurent Monney , Jason L. Gaglia , Edward A. Greenfield , Gordon J. Freeman , Hanspeter Waldner
- Applicant Address: US MA Boston US MA Boston
- Assignee: Dana-Farber Cancer Institute,The Brigham and Women's Hospital, Inc.
- Current Assignee: Dana-Farber Cancer Institute,The Brigham and Women's Hospital, Inc.
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Mark J. FitzGerald
- Main IPC: A61K39/395
- IPC: A61K39/395
Abstract:
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.
Public/Granted literature
- US20120315286A1 COMPOSITIONS AND METHODS RELATED TO TIM 3, A TH1-SPECIFIC CELL SURFACE MOLECULE Public/Granted day:2012-12-13
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