中科微点-全球专利检索

  1. Login
  2. Sign Up
Invention Grant
US08697087B2 Influenza vaccines including combinations of particulate adjuvants and immunopotentiators 失效
流感疫苗，包括颗粒状佐剂和免疫增强剂的组合

  • Patent Title: Influenza vaccines including combinations of particulate adjuvants and immunopotentiators
  • Patent Title (中): 流感疫苗，包括颗粒状佐剂和免疫增强剂的组合
  • Application No.: US12092162
    Application Date: 2006-11-06
  • Publication No.: US08697087B2
    Publication Date: 2014-04-15
  • Inventor: Rino Rappuoli , Derek O'Hagan , Giuseppe Del Giudice
  • Applicant: Rino Rappuoli , Derek O'Hagan , Giuseppe Del Giudice
  • Applicant Address: CH Basel
  • Assignee: Novartis AG
  • Current Assignee: Novartis AG
  • Current Assignee Address: CH Basel
  • Agent Helen Lee; Otis Littlefield
  • International Application: PCT/GB2006/004133 WO 20061106
  • International Announcement: WO2007/052058 WO 20070510
  • Main IPC: A61K39/39
  • IPC: A61K39/39 ;  C12N1/20
Influenza vaccines including combinations of particulate adjuvants and immunopotentiators
Abstract:
Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) a immunopotentiator.
Abstract(Chinese):

已经发现含有不溶性颗粒佐剂的流感疫苗引起主要是TH2应答（IgG1）的IgG应答。 通过在组合物中包含免疫增强剂，该反应可以转向TH1反应（IgG2a）。 因此，本发明提供免疫原性组合物，其包含：（i）流感病毒抗原; （ii）不溶性颗粒佐剂; 和（iii）免疫增强剂。

Public/Granted literature
Information query
Espacenet
Patent Agency Ranking
0/0