Invention Grant
- Patent Title: Tape preparation comprising etodolac in ionic liquid form
- Patent Title (中): 包含离子液体形式的依托度酸的胶带制剂
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Application No.: US12746632Application Date: 2008-12-09
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Publication No.: US08697096B2Publication Date: 2014-04-15
- Inventor: Hidetoshi Hamamoto , Yasushi Miwa
- Applicant: Hidetoshi Hamamoto , Yasushi Miwa
- Applicant Address: JP Kagawa
- Assignee: MEDRx Co., Ltd.
- Current Assignee: MEDRx Co., Ltd.
- Current Assignee Address: JP Kagawa
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2007-320125 20071211
- International Application: PCT/JP2008/003659 WO 20081209
- International Announcement: WO2009/075094 WO 20090618
- Main IPC: A61K9/00
- IPC: A61K9/00

Abstract:
Disclosed is a tape preparation comprising etodolac in an ionic liquid form, which has high transdermal absorbability. Etodolac is reacted with an organic amine compound to produce an ionic liquid of etodolac. By using the ionic liquid, it becomes possible to increase the transdermal absorbability of etodolac. Further for the purpose of enhancing the transdermal absorbability and the tissue penetration ability of an ionic solution of etodolac, the composition of an organic solvent system for the ionic solution of etodolac is investigated, and it is found that a mixed solvent of an alcohol and an ester (1:2 to 2:1) is suitable as the organic solvent. Still further, an appropriate adhesion force can be achieved by properly selecting a softening agent. In this manner, a tape preparation having good transdermal absorbability can be prepared. The tape preparation can exert its pharmacological efficacy rapidly, and is therefore extremely effective for the teatment of a chronic pain such as rheumatoid arthritis, osteoarthritis and lumbago, an inflammatory diseases such as shoulder periarthritis and tendovaginitis, cervical syndrome, a pain induced by a surgery or an injury, or the like.
Public/Granted literature
- US20100280090A1 TAPE PREPARATION COMPRISING ETODOLAC IN IONIC LIQUID FORM Public/Granted day:2010-11-04
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