Invention Grant
US08697395B2 Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
有权
使用大范围核酸酶从体外诱导同源重组,并在脊椎动物体细胞中诱导同源重组及其应用
- Patent Title: Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
- Patent Title (中): 使用大范围核酸酶从体外诱导同源重组,并在脊椎动物体细胞中诱导同源重组及其应用
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Application No.: US13556206Application Date: 2012-07-24
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Publication No.: US08697395B2Publication Date: 2014-04-15
- Inventor: Sylvain Arnould , Patrick Chames , Phillippe Duchateau , Jean-Charles Epinat , Emmanuel Lacroix , Frederic Paques
- Applicant: Sylvain Arnould , Patrick Chames , Phillippe Duchateau , Jean-Charles Epinat , Emmanuel Lacroix , Frederic Paques
- Applicant Address: FR Paris
- Assignee: Cellectis S.A.
- Current Assignee: Cellectis S.A.
- Current Assignee Address: FR Paris
- Agency: Kenyon & Kenyon LLP
- Main IPC: C12N9/22
- IPC: C12N9/22 ; C12N15/00 ; C12N15/11 ; C12N15/55

Abstract:
Use of meganucleases for cleaving DNA in a non-human or an isolated human cell and, in some instances, inducing homologous recombination in said cells and to its application for genome engineering and gene therapy.
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