Invention Grant
US08697417B2 Baculoviral vectors comprising repeated coding sequences with differential codon biases
有权
杆状病毒载体包含具有差异密码子偏差的重复编码序列
- Patent Title: Baculoviral vectors comprising repeated coding sequences with differential codon biases
- Patent Title (中): 杆状病毒载体包含具有差异密码子偏差的重复编码序列
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Application No.: US12670780Application Date: 2008-07-25
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Publication No.: US08697417B2Publication Date: 2014-04-15
- Inventor: Andrew Christian Bakker , Wilhelmus Theodorus Johannes Maria Christiaan Hermens
- Applicant: Andrew Christian Bakker , Wilhelmus Theodorus Johannes Maria Christiaan Hermens
- Applicant Address: NL Amsterdam
- Assignee: Uniqure IP B.V.
- Current Assignee: Uniqure IP B.V.
- Current Assignee Address: NL Amsterdam
- Agency: Browdy and Neimark, PLLC
- Priority: EP07113257 20070726
- International Application: PCT/NL2008/050512 WO 20080725
- International Announcement: WO2009/014445 WO 20090129
- Main IPC: C12N7/00
- IPC: C12N7/00 ; C12N7/01 ; C12N7/02 ; C12N5/10
Abstract:
The present invention relates to production of proteins in insect cells whereby repeated coding sequences are used in baculoviral vectors. In particular the invention relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral rep proteins that increase the productivity of parvoviral vectors.
Public/Granted literature
- US20100261254A1 BACULOVIRAL VECTORS COMPRISING REPEATED CODING SEQUENCES WITH DIFFERENTIAL CODON BIASES Public/Granted day:2010-10-14
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