Invention Grant
US08697440B2 Compositions and methods for producing gamma-carboxylated proteins
有权
用于产生γ-羧化蛋白质的组合物和方法
- Patent Title: Compositions and methods for producing gamma-carboxylated proteins
- Patent Title (中): 用于产生γ-羧化蛋白质的组合物和方法
-
Application No.: US12950713Application Date: 2010-11-19
-
Publication No.: US08697440B2Publication Date: 2014-04-15
- Inventor: Christel Fenge , Ann Lövgren , Anders Thelin
- Applicant: Christel Fenge , Ann Lövgren , Anders Thelin
- Applicant Address: GB Cambridge
- Assignee: Medimmune Limited
- Current Assignee: Medimmune Limited
- Current Assignee Address: GB Cambridge
- Priority: GB0324044.7 20031014
- Main IPC: C12N5/07
- IPC: C12N5/07 ; C12N15/00
Abstract:
The present invention relates to methods and tools for producing large quantities of gamma-carboxylated protein comprising: (i) culturing a cell adapted to express a protein which requires gamma-carboxylation and γ-glutamyl carboxylase in a ratio of at least 10:1, under conditions suitable for expression of both proteins, and (ii) isolating gamma-carboxylated protein.
Public/Granted literature
- US20110092429A1 COMPOSITIONS AND METHODS FOR PRODUCING GAMMA-CARBOXYLATED PROTEINS Public/Granted day:2011-04-21
Information query
