Invention Grant
US08697444B2 Compositions for the in vitro derivation and culture of embryonic stem (ES) cell lines with germline transmission capability and for the culture of adult stem cells
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用于具有种系传播能力和成体干细胞培养的胚胎干（ES）细胞系的体外衍生和培养的组合物
- Patent Title: Compositions for the in vitro derivation and culture of embryonic stem (ES) cell lines with germline transmission capability and for the culture of adult stem cells
- Patent Title (中): 用于具有种系传播能力和成体干细胞培养的胚胎干（ES）细胞系的体外衍生和培养的组合物
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Application No.: US12274939Application Date: 2008-11-20
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Publication No.: US08697444B2Publication Date: 2014-04-15
- Inventor: Luc Schoonjans
- Applicant: Luc Schoonjans
- Applicant Address: BE Leuven
- Assignee: Thrombogenics N.V.
- Current Assignee: Thrombogenics N.V.
- Current Assignee Address: BE Leuven
- Agency: Clark & Elbing LLP
- Priority: WOPCT/BE01/00221 20011221; GB0220145.7 20020830
- Main IPC: C12N5/02
- IPC: C12N5/02 ; C12N5/00 ; C12N5/08
Abstract:
The present invention encompasses compositions for deriving, maintaining, and growing pluripotent and germ-line competent mammalian embryonic stem cells, and for deriving, maintaining, and growing adult human stem cells and/or adult early progenitor cells. Such compositions comprising a conditioned medium of a cell line expressing limited amounts of Leukemia Inhibitory Factor (LIF). The media of the present invention are used or for the generation of pluripotent and germ-line competent embryonic stem cells of mammals, and for the generation of adult human stem cells and/or adult early progenitor cells.
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