Invention Grant
US08697689B2 Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
有权
吲哚和苯并吗啉衍生物作为代谢型谷氨酸受体的调节剂
- Patent Title: Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
- Patent Title (中): 吲哚和苯并吗啉衍生物作为代谢型谷氨酸受体的调节剂
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Application No.: US13123984Application Date: 2009-10-15
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Publication No.: US08697689B2Publication Date: 2014-04-15
- Inventor: Jose Maria Cid-Nunez , Andres Avelino Trabanco-Suarez
- Applicant: Jose Maria Cid-Nunez , Andres Avelino Trabanco-Suarez
- Applicant Address: US NJ Titusville CH Geneva
- Assignee: Janssen Pharmaceuticals, Inc.,Addex Pharma SA
- Current Assignee: Janssen Pharmaceuticals, Inc.,Addex Pharma SA
- Current Assignee Address: US NJ Titusville CH Geneva
- Agency: Baker & Hostetler LLP
- Priority: EP08166832 20081016
- International Application: PCT/EP2009/007404 WO 20091015
- International Announcement: WO2010/043396 WO 20100422
- Main IPC: C07D403/04
- IPC: C07D403/04 ; C07D413/04 ; C07D413/14 ; A61K31/4433 ; A61K31/4439

Abstract:
The present invention relates to novel compounds, in particular novel indole and benzomorpholine derivatives according to Formula (I) wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors—subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions as well as to the use of such compounds or compositions for the prevention and treatment of such diseases in which mGluR2 is involved.
Public/Granted literature
- US20110275624A1 INDOLE AND BENZOMORPHOLINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS Public/Granted day:2011-11-10
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