Invention Grant
US08697689B2 Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors 有权
吲哚和苯并吗啉衍生物作为代谢型谷氨酸受体的调节剂

Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
Abstract:
The present invention relates to novel compounds, in particular novel indole and benzomorpholine derivatives according to Formula (I) wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors—subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions as well as to the use of such compounds or compositions for the prevention and treatment of such diseases in which mGluR2 is involved.
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