Invention Grant
- Patent Title: Isoindolone M1 receptor positive allosteric modulators
- Patent Title (中): 异吲哚酮M1受体阳性变构调节剂
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Application No.: US13805346Application Date: 2011-06-27
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Publication No.: US08697690B2Publication Date: 2014-04-15
- Inventor: Douglas C. Beshore , Scott D. Kuduk , Youheng Shu , Zhi-Qiang Yang
- Applicant: Douglas C. Beshore , Scott D. Kuduk , Youheng Shu , Zhi-Qiang Yang
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; John C. Todaro
- International Application: PCT/US2011/041933 WO 20110627
- International Announcement: WO2012/003147 WO 20120105
- Main IPC: C07D209/62
- IPC: C07D209/62 ; C07D405/04 ; C07D401/14 ; C07D471/04 ; C07D401/10 ; C07D405/14
Abstract:
The present invention is directed to isoindolone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
Public/Granted literature
- US20130109686A1 ISOINDOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS Public/Granted day:2013-05-02
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