Invention Grant
- Patent Title: Solid forms of epalrestat
- Patent Title (中): epalrestat的固体形式
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Application No.: US13013786Application Date: 2011-01-25
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Publication No.: US08697735B2Publication Date: 2014-04-15
- Inventor: Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Jeffrey S. Stults , Travis L. Houston
- Applicant: Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Jeffrey S. Stults , Travis L. Houston
- Applicant Address: US MA Cambridge
- Assignee: Bionevia Pharmaceuticals, Inc.
- Current Assignee: Bionevia Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: The Marbury Law Group, PLLC
- Main IPC: A61K31/426
- IPC: A61K31/426 ; C07D277/36
Abstract:
The invention relates to novel crystalline salts of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid and a novel betaine cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel crystalline salts and cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel crystalline salts and cocrystal and the therapeutic use of the novel crystalline salts and cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, inhibiting aldose reductase, and affording cardioprotection in patients who may be non-diabetic.
Public/Granted literature
- US20110275681A1 NOVEL SOLID FORMS OF EPALRESTAT Public/Granted day:2011-11-10
Information query
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