Invention Grant
US08697736B2 1H-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent PARP inhibitors
有权
在2-位被苯基取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂
- Patent Title: 1H-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent PARP inhibitors
- Patent Title (中): 在2-位被苯基取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂
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Application No.: US11536994Application Date: 2006-09-29
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Publication No.: US08697736B2Publication Date: 2014-04-15
- Inventor: Thomas D. Penning , Sheela A. Thomas , Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Vincent L. Giranda
- Applicant: Thomas D. Penning , Sheela A. Thomas , Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Vincent L. Giranda
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agency: Michael Best & Friedrich LLP
- Agent Lisa V. Mueller
- Main IPC: A61K31/4184
- IPC: A61K31/4184 ; C07D403/10
Abstract:
Compound having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
Public/Granted literature
- US20070179136A1 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS Public/Granted day:2007-08-02
Information query
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