Invention Grant
US08697869B2 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives and their use as prostaglandin D2 receptor modulators
有权
3-（杂芳基 - 氨基）-1,2,3,4-四氢-9H-咔唑衍生物及其作为前列腺素D2受体调节剂的用途
- Patent Title: 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives and their use as prostaglandin D2 receptor modulators
- Patent Title (中): 3-（杂芳基 - 氨基）-1,2,3,4-四氢-9H-咔唑衍生物及其作为前列腺素D2受体调节剂的用途
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Application No.: US13637005Application Date: 2011-03-21
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Publication No.: US08697869B2Publication Date: 2014-04-15
- Inventor: Hamed Aissaoui , Heinz Fretz , Julien Hazemann , Sylvia Richard-Bildstein , Romain Siegrist
- Applicant: Hamed Aissaoui , Heinz Fretz , Julien Hazemann , Sylvia Richard-Bildstein , Romain Siegrist
- Applicant Address: CH Allschwil
- Assignee: Actelion Pharmaceuticals Ltd.
- Current Assignee: Actelion Pharmaceuticals Ltd.
- Current Assignee Address: CH Allschwil
- Agency: Hunton & Williams LLP
- Priority: WOPCT/IB2010/051228 20100322
- International Application: PCT/IB2011/051165 WO 20110321
- International Announcement: WO2011/117798 WO 20110929
- Main IPC: C07D239/02
- IPC: C07D239/02 ; A61K31/50
Abstract:
The present invention relates to 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives of the formula (I), wherein R1, R2 and R3 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
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