Invention Grant
- Patent Title: Heterocyclic compound and use thereof
- Patent Title (中): 杂环化合物及其用途
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Application No.: US13132253Application Date: 2009-11-30
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Publication No.: US08697874B2Publication Date: 2014-04-15
- Inventor: Masanori Okaniwa
- Applicant: Masanori Okaniwa
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: JP2008-306614 20081201
- International Application: PCT/JP2009/070131 WO 20091130
- International Announcement: WO2010/064611 WO 20100610
- Main IPC: C07D513/04
- IPC: C07D513/04 ; A61K31/4365

Abstract:
A compound represented by formula (I) or a salt thereof, which has a potent Raf inhibitory activity. In formula (I), R1 represents an optionally substituted C1-6 alkyl, etc.; X represents —O— or —NR2— (wherein R2 represents a hydrogen atom or a C1-6 alkyl); Y represents a group represented by formula 2 (2i or 2ii) (wherein ring A represents an optionally substituted benzene ring; Z represents a group represented by (1) —NR3CO—W1—, (2) —NR3CO—W1—O—, (3) —NR3CO—W1—O—W2—, (4) —NR3CO—W1—S—, (5) —NR3CO—W1—NR4—, (6) —NR3COO—, (7) —NR3COO—W1—, (8) —NR3CO—CO—, or (9) —NR3CONR4— (wherein R3 and R4 each represents a hydrogen atom, etc., and W1 and W2 each represents an optionally substituted C1-6 alkylene, etc.); and R5 represents an optionally substituted five- or six-membered ring group.
Public/Granted literature
- US20110237620A1 HETEROCYCLIC COMPOUND AND USE THEREOF Public/Granted day:2011-09-29
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