A multi-factor optimized routing can select a computing device, from among multiple computing devices associated with a domain, to receive communications and thereby optimize one or more factors associated with such communications. Such multi-factor optimized routing can likewise specify a particular route, such as through the specification of one or more sub-networks. A performance monitoring system, comprising a performance monitoring framework that can support service-specific performance monitors can collect performance data to be used in the selection of a multi-factor optimized route. Additional data can be collected from other sources and the multi-factor optimized routing can be provided to a name resolution and routing system to ultimately route communications in an optimized manner.