Provided are a method, system, and computer program product for processing read and write requests in a storage controller. A host adaptor in the storage controller receives a write request from a host system for a storage address in a storage device. The host adaptor sends write information indicating the storage address updated by the write request to a device adaptor in the storage controller. The host adaptor writes the write data to a cache in the storage controller. The device adaptor indicates the storage address indicated in the write information to a modified storage address list stored in the device adaptor, wherein the modified storage address list indicates modified data in the cache for storage addresses in the storage device.