The delivery of targeted advertisements (ads) to wireless mobile handheld display devices (MHDDs) with client specific advertisement and dynamic content for response and feedback is becoming important in advertising. As the return for ads on MHDDs becomes higher, there is a push to show larger and more interactive ads on devices that have small displays. This has created a need to maximize the area available for ad viewing. The need for larger viewing area reduces the area available for call-to-action response enabling switches or inserts on the screen for customer interaction. To overcome this deficiency and provide the necessary end-to-end response capability, hot-spots on the ad image are provided as call-to-action response regions without limitation on the ad viewing area. The use of such hot-spots provides users of MHDDs a preferred interaction mechanism for responding to the advertisement, while maintaining a large ad viewing area.