Invention Grant
- Patent Title: Method for obtaining biologically active recombinant human G-CSF
- Patent Title (中): 获得生物活性重组人G-CSF的方法
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Application No.: US13634801Application Date: 2011-03-17
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Publication No.: US08703123B2Publication Date: 2014-04-22
- Inventor: Walter Hinderer , Christian Scheckermann
- Applicant: Walter Hinderer , Christian Scheckermann
- Applicant Address: DE Ulm
- Assignee: BioGeneriX GmbH
- Current Assignee: BioGeneriX GmbH
- Current Assignee Address: DE Ulm
- Agency: Cooper & Dunham LLP
- Agent John P. White
- Priority: EP10002811 20100317
- International Application: PCT/EP2011/001331 WO 20110317
- International Announcement: WO2011/113601 WO 20110922
- Main IPC: A61K35/00
- IPC: A61K35/00 ; C07K1/16 ; C07K1/18 ; C07K1/20
Abstract:
Provided is a method of obtaining biologically active recombinant human G-CSF from inclusion bodies, wherein the solubilization and refolding process can be performed at ambient temperature and the purification step comprises reversed phase chromatography (RP), in particular RP-HPLC. The G-CSF preparation so obtained is characterized by high purity and homogeneity.
Public/Granted literature
- US20120328560A1 METHOD FOR OBTAINING BIOLOGICALLY ACTIVE RECOMBINANT HUMAN G-CSF Public/Granted day:2012-12-27
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