Invention Grant
US08703125B2 Modulation of the Vps10p-domain receptor family for the treatment of mental and behavioural disorders
有权
调节Vps10p结构域受体家族用于治疗精神和行为障碍
- Patent Title: Modulation of the Vps10p-domain receptor family for the treatment of mental and behavioural disorders
- Patent Title (中): 调节Vps10p结构域受体家族用于治疗精神和行为障碍
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Application No.: US13140515Application Date: 2009-12-17
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Publication No.: US08703125B2Publication Date: 2014-04-22
- Inventor: Simon Glerup Pedersen , Ulrich Bølcho , Kimmo Jensen , Anders Nykjær
- Applicant: Simon Glerup Pedersen , Ulrich Bølcho , Kimmo Jensen , Anders Nykjær
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agent Mary Catherine Di Nunzio
- Priority: DK200801825 20081219
- International Application: PCT/DK2009/050341 WO 20091217
- International Announcement: WO2010/069331 WO 20100624
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28
Abstract:
The present invention relates to methods for modulating the activity of one or more Vps10p-domain receptors selected from the group consisting of Sortilin, SorLA, SorCS1, SorCS2 and SorCS3, in an animal and methods for preparation of a medicament for the treatment of mental and behavioral disorders. The modulation is carried out by inhibiting or promoting the binding of ligands to the Vps10p-domain receptor. In vitro and in vivo methods for screening for agents capable of modulation of said Vps10p-domain receptor activity are also provided. The invention further-more relates to methods of altering expression of said receptors in vivo.
Public/Granted literature
- US20120052075A1 MODULATION OF THE VPS10P-DOMAIN RECEPTOR FAMILY FOR THE TREATMENT OF MENTAL AND BEHAVIOURAL DISORDERS Public/Granted day:2012-03-01
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