Invention Grant
- Patent Title: HCV coreceptor and methods of use thereof
- Patent Title (中): HCV共受体及其使用方法
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Application No.: US13215820Application Date: 2011-08-23
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Publication No.: US08703149B2Publication Date: 2014-04-22
- Inventor: Charles Rice , Matthew J. Evans , Thomas Von Hahn
- Applicant: Charles Rice , Matthew J. Evans , Thomas Von Hahn
- Applicant Address: US NY New York
- Assignee: The Rockefeller University
- Current Assignee: The Rockefeller University
- Current Assignee Address: US NY New York
- Agency: Thompson Coburn LLP
- Agent Charles P. Romano
- Main IPC: A61K39/29
- IPC: A61K39/29 ; A61K39/395 ; C07K16/00
Abstract:
The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying agents or compounds that interfere with HCV interactions with Claudin-1 are also provided. Finally, useful kits, cell culture compositions, agents, and compounds related to the inhibition of HCV interactions with Claudin-1 are also disclosed.
Public/Granted literature
- US20120054879A1 HCV Coreceptor and Methods of Use Thereof Public/Granted day:2012-03-01
Information query
