Invention Grant
- Patent Title: Salmonella vectored vaccines against Chlamydia and methods of use
- Patent Title (中): 沙门氏菌针对衣原体的疫苗和使用方法
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Application No.: US12999246Application Date: 2009-06-16
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Publication No.: US08703153B2Publication Date: 2014-04-22
- Inventor: Jonathan Lewis Telfer , Mark Richard Redfern , Michael Joseph Lacy
- Applicant: Jonathan Lewis Telfer , Mark Richard Redfern , Michael Joseph Lacy
- Assignee: Prokarium Ltd.
- Current Assignee: Prokarium Ltd.
- Agency: Cooley LLP
- International Application: PCT/US2009/047542 WO 20090616
- International Announcement: WO2009/158240 WO 20091230
- Main IPC: A61K39/112
- IPC: A61K39/112 ; A61K48/00 ; A61K49/00

Abstract:
The invention provides an attenuated Salmonella vaccine vector comprising one or more heterologous polynucleotides that encode immunogenic Chlamydial peptides. In one embodiment, the attenuated Salmonella vaccine vector comprises aroC and ssaV attenuating mutations. The heterologous polynucleotides encoding the immunogenic Chlamydial peptides can be under the control of an inducible promoter such as a Salmonella ssaG promoter. In one embodiment of the invention, the immunogenic Chlamydial peptide is a PmpG peptide, for instance, a CT110, CT84 or CT40 peptide.
Public/Granted literature
- US20110268760A1 SALMONELLA VECTORED VACCINES AGAINST CHLAMYDIA AND METHODS OF USE Public/Granted day:2011-11-03
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