Invention Grant
- Patent Title: Pichia pastoris deficient in endogenous secreted protease
- Patent Title (中): 巴斯德毕赤酵母缺乏内源性分泌蛋白酶
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Application No.: US13515577Application Date: 2010-12-13
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Publication No.: US08703444B2Publication Date: 2014-04-22
- Inventor: Michel Monod
- Applicant: Michel Monod
- Applicant Address: CH Lausanne
- Assignee: Centre Hospitalier Universitaire Vaudois (CHUV)
- Current Assignee: Centre Hospitalier Universitaire Vaudois (CHUV)
- Current Assignee Address: CH Lausanne
- Agency: Harness, Dickey & Pierce, P.L.C.
- International Application: PCT/IB2010/055777 WO 20101213
- International Announcement: WO2011/073883 WO 20110623
- Main IPC: C12N9/60
- IPC: C12N9/60
Abstract:
The present invention relates to micro-organisms and to methods of producing proteins. More specifically, the inventions relates to a host cell useful for the expression of heterozygous proteins in which the host cell, Pichia pastoris, has been genetically modified so that the gene for endogenous secreted subtilisin Sub2 protease is completely or partially inactivated.
Public/Granted literature
- US20120295307A1 PICHIA PASTORIS DEFICIENT IN ENDOGENOUS SECRETED PROTEASE Public/Granted day:2012-11-22
Information query
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