Invention Grant
US08703459B2 Catalytic domains of beta(1,4)-galactosyltransferase I having altered metal ion specificity
失效
具有改变的金属离子特异性的β（1,4） - 半乳糖转移酶I的催化结构域
- Patent Title: Catalytic domains of beta(1,4)-galactosyltransferase I having altered metal ion specificity
- Patent Title (中): 具有改变的金属离子特异性的β（1,4） - 半乳糖转移酶I的催化结构域
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Application No.: US10581942Application Date: 2004-12-06
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Publication No.: US08703459B2Publication Date: 2014-04-22
- Inventor: Pradman Qasba , Elizabeth Boeggeman , Boopathy Ramakrishnan
- Applicant: Pradman Qasba , Elizabeth Boeggeman , Boopathy Ramakrishnan
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee Address: US DC Washington
- Agency: Edwards Wildman Palmer LLP
- Agent Peter F. Corless
- International Application: PCT/US2004/040844 WO 20041206
- International Announcement: WO2005/056783 WO 20050623
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C12N5/16 ; C12N15/00 ; C12P21/06 ; C07H21/04
Abstract:
Disclosed are mutants of galactosyltransferases that can catalyze formation of oligosaccharides in the presence of magnesium; mutants of galactosyltransferases having altered donor and acceptor specificity which can catalyze formation of oligosaccharides in the presence of magnesium; methods and compositions that can be used to synthesize oligosaccharides; methods for increasing the immunogenicity of an antigen; and methods to stabilize platelets.
Public/Granted literature
- US20080199905A1 Catalytic Domains Of Beta(1,4)-Galactosyltransferase I Having Altered Metal Ion Specificity Public/Granted day:2008-08-21
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