Invention Grant
US08703487B2 Compositions and methods for making and using bone marrow mesenchymal stem cells and erythroid progenitor cells
有权
用于制造和使用骨髓间充质干细胞和红细胞祖细胞的组合物和方法
- Patent Title: Compositions and methods for making and using bone marrow mesenchymal stem cells and erythroid progenitor cells
- Patent Title (中): 用于制造和使用骨髓间充质干细胞和红细胞祖细胞的组合物和方法
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Application No.: US13512872Application Date: 2010-11-30
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Publication No.: US08703487B2Publication Date: 2014-04-22
- Inventor: Ewa Carrier
- Applicant: Ewa Carrier
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Gavrilovich, Dodd & Lindsey LLP
- Agent Gregory P. Einhorn
- International Application: PCT/US2010/058384 WO 20101130
- International Announcement: WO2011/068792 WO 20110609
- Main IPC: C12N5/07
- IPC: C12N5/07 ; C12N5/071
Abstract:
The invention provides compositions for making erythroid progenitor cells that comprise in vitro-activated bone marrow mesenchymal stem cells and embryoid bodies (EBs) or pluripotent stem cells, and methods for making and using them, including ameliorating (e.g., preventing or treating) anemia and/or stimulating erythropoiesis. In one embodiment, the invention provides methods of increasing propensity of committed stem cell differentiation towards the erythroid lineage.
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