Invention Grant
- Patent Title: Targeting cancer stem cells with DR5 agonists
- Patent Title (中): 用DR5激动剂靶向癌症干细胞
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Application No.: US13634401Application Date: 2011-03-18
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Publication No.: US08703712B2Publication Date: 2014-04-22
- Inventor: Donald J. Buchsbaum , Albert F. Lobuglio , Tong Zhou , Kimberly Foreman
- Applicant: Donald J. Buchsbaum , Albert F. Lobuglio , Tong Zhou , Kimberly Foreman
- Applicant Address: US AL Birmingham
- Assignee: The UAB Research Foundation
- Current Assignee: The UAB Research Foundation
- Current Assignee Address: US AL Birmingham
- Agency: Kilpatrick, Townsend & Stockton LLP
- International Application: PCT/US2011/029081 WO 20110318
- International Announcement: WO2011/116344 WO 20110922
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61P35/00 ; A61K39/395 ; C12N5/095 ; C07K16/30
Abstract:
Provided is a method of determining the level of resistance or sensitivity of cancer stem cells to a death receptor agonist. The method includes detecting the level of IAP in one or more DR5/DDX3/IAP complexes in or from the cancer stem cells. Also provided is a method of killing cancer stem cells in a subject and a method of reducing the risk of cancer recurrence in a subject.
Public/Granted literature
- US20130004521A1 TARGETING CANCER STEM CELLS Public/Granted day:2013-01-03
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