Invention Grant
US08703752B2 Use of mifepristone and derivatives therefor as Hedgehog protein signaling pathway modulators and applications of same
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使用米非司酮及其衍生物作为Hedgehog蛋白信号通路调节剂及其应用
- Patent Title: Use of mifepristone and derivatives therefor as Hedgehog protein signaling pathway modulators and applications of same
- Patent Title (中): 使用米非司酮及其衍生物作为Hedgehog蛋白信号通路调节剂及其应用
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Application No.: US10543004Application Date: 2004-01-22
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Publication No.: US08703752B2Publication Date: 2014-04-22
- Inventor: Martial Ruat , Elisabeth Traiffort , Hélène Faure
- Applicant: Martial Ruat , Elisabeth Traiffort , Hélène Faure
- Applicant Address: FR Paris Cedex
- Assignee: Centre National de la Recherche Scientifique
- Current Assignee: Centre National de la Recherche Scientifique
- Current Assignee Address: FR Paris Cedex
- Agency: Morgan, Lewis & Bockius LLP
- Priority: FR0300646 20030122
- International Application: PCT/FR2004/000151 WO 20040122
- International Announcement: WO2004/067550 WO 20040812
- Main IPC: A01N45/00
- IPC: A01N45/00 ; A01N57/00 ; A61K31/56 ; A61K31/66
Abstract:
The invention relates to a novel use of compounds having formula (I), including mifepristone (RU 486 or RU 38 486) and the derivative salts thereof, for the preparation of a medicament that can modulate (activate or inhibit) the Hedgehog protein signalling pathway, which is intended for the treatment of pathologies involving a tissue dysfunction linked to deregulation of said pathway.
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