Invention Grant
US08703791B2 3-carboxypropyl-aminotetralin derivatives and related compounds as mu opioid receptor antagonists
有权
3-羧丙基 - 氨基四氢萘衍生物和相关化合物作为μ阿片受体拮抗剂
- Patent Title: 3-carboxypropyl-aminotetralin derivatives and related compounds as mu opioid receptor antagonists
- Patent Title (中): 3-羧丙基 - 氨基四氢萘衍生物和相关化合物作为μ阿片受体拮抗剂
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Application No.: US13921448Application Date: 2013-06-19
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Publication No.: US08703791B2Publication Date: 2014-04-22
- Inventor: Sean G. Trapp , Michael R. Leadbetter , Daniel D. Long , John R. Jacobsen , Priscilla Van Dyke
- Applicant: Sean G. Trapp , Michael R. Leadbetter , Daniel D. Long , John R. Jacobsen , Priscilla Van Dyke
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Roberta P. Saxon
- Main IPC: A01N43/42
- IPC: A01N43/42
Abstract:
The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, and R6 are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
Public/Granted literature
- US20140031380A1 3-CARBOXYPROPYL-AMINOTETRALIN DERIVATIVES AND RELATED COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS Public/Granted day:2014-01-30
Information query
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