Invention Grant
US08703797B2 Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (S1P2) receptors
失效
缩合环吡啶化合物作为鞘氨醇-1-磷酸-2（S1P2）受体的亚型选择性调节剂
- Patent Title: Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (S1P2) receptors
- Patent Title (中): 缩合环吡啶化合物作为鞘氨醇-1-磷酸-2（S1P2）受体的亚型选择性调节剂
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Application No.: US13929451Application Date: 2013-06-27
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Publication No.: US08703797B2Publication Date: 2014-04-22
- Inventor: Wenkui K. Fang , Evelyn G. Corpuz , Wha-Bin Im , Ken Chow , Liming Wang
- Applicant: Allergan, Inc.
- Applicant Address: US CA Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: US CA Irvine
- Agent Doina G. Ene
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D215/38
Abstract:
The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity, wherein these compounds selected from the group consisting of wherein A, B, C, D, X, Y, Z and R3 are defined in the specification. Said compounds are useful for treating a disease or condition of a mammal selected from the group consisting of ocular diseases; systemic vascular barrier related diseases; allergies and other inflammatory diseases; cardiac diseases or conditions; fibrosis; pain and wounds.
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