Invention Grant
- Patent Title: Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
- Patent Title (中): 用于转染核酸的二硫键连接的聚乙二醇/肽缀合物
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Application No.: US13378241Application Date: 2010-09-03
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Publication No.: US08703906B2Publication Date: 2014-04-22
- Inventor: Patrick Baumhof , Thomas Schlake
- Applicant: Patrick Baumhof , Thomas Schlake
- Applicant Address: DE Tuebingen
- Assignee: CureVac GmbH
- Current Assignee: CureVac GmbH
- Current Assignee Address: DE Tuebingen
- Agency: Parker Highlander PLLC
- International Application: PCT/EP2010/005438 WO 20100903
- International Announcement: WO2011/026641 WO 20110310
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K2/00 ; C07K4/00 ; C07K5/00 ; C07K7/00 ; C07K14/00 ; C07K16/00 ; C07K17/00
Abstract:
The present invention is directed to an inventive polymeric carrier molecule according to generic formula (I) and variations thereof, which allows for efficient transfection of nucleic acids into cells in vivo and in vitro, a polymeric carrier cargo complex formed by a nucleic acid and the inventive polymeric carrier molecule, but also to methods of preparation of this inventive polymeric carrier molecule and of the inventive polymeric carrier cargo complex. The present invention also provides methods of application and use of this inventive polymeric carrier molecule and the inventive polymeric carrier cargo complex as a medicament, for the treatment of various diseases, and in the preparation of a pharmaceutical composition for the treatment of such diseases.
Public/Granted literature
- US20120219573A1 DISULFIDE-LINKED POLYETHYLENEGLYCOL/PEPTIDE CONJUGATES FOR THE TRANSFECTION OF NUCLEIC ACIDS Public/Granted day:2012-08-30
Information query
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