Invention Grant
- Patent Title: Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof
- Patent Title (中): 制备磺达肝素钠的方法和可用于其合成的中间体
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Application No.: US13618786Application Date: 2012-09-14
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Publication No.: US08703923B2Publication Date: 2014-04-22
- Inventor: Sourena Nadji , James T. Smoot , Joseph A. Vanartsdalen
- Applicant: Sourena Nadji , James T. Smoot , Joseph A. Vanartsdalen
- Applicant Address: US MO St. Louis
- Assignee: Reliable Biopharmaceutical Corporation
- Current Assignee: Reliable Biopharmaceutical Corporation
- Current Assignee Address: US MO St. Louis
- Agency: Blank Rome LLP
- Main IPC: C07G3/00
- IPC: C07G3/00 ; C07H15/00 ; C07H17/00
Abstract:
Processes for the synthesis of the Factor Xa anticoagulent Fondaparinux, and related compounds are described. Also described are protected pentasaccharide intermediates as well as efficient and scalable processes for the industrial scale production of Fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions.
Public/Granted literature
- US20130102764A1 PROCESS FOR PERPARING FONDAPARINUX SODIUM AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF Public/Granted day:2013-04-25
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