Embodiments of the present disclosure relate to customization of user interfaces for medical devices. According to certain embodiments, patient monitors may include a device body designed to interface with interchangeable and removable faceplates. The faceplates may include input devices for controlling the patient monitor. Further, the properties of the input devices, such as the size, shape, labels, type, and location, may vary between faceplates. Further, in certain embodiments, the faceplates may include a memory for storing preferences associated with the user interface.