A method for quantification of the desynchronization between the clocks of two medical devices communicating wirelessly, for example, by HBC signals. The devices are separately clocked by slow clocks (CLK1/32k, CLK2/32k) and include selectively activated fast clocks (CLK1/10M, CLK2/10M). The method comprises: a) on a predetermined transition (T1) of a slow clock, transmission by one device of a synchronization query signal (SYNC) to the other device, b) counting of the pulses of the activated fast clock to detect a predetermined transition (T3) of the first slow clock, then c) transmitting from the other device to the first device a response signal (D1) and d) upon reception of the response signal, computing a temporal shift (OFFSET) according to the result (D1, D2) of the counting of the pulses of the fast clock. Two fast clocks, one on each device, also can be used.