Described technologies are generally related to predicting future mobile device locations and using the predictive information to optimize mobile communications service parameters. Mobile device locations may be predicted using real-time device location information, destination information, and location history. Predicted location information for a given device, and possibly other devices as well, may be used to adjust mobile communications service parameters such as handoffs, channel assignment, multipath fading response parameters, data rates, transmission modes, opportunistic scheduling parameters, location-based services, and location update rates.