A method and apparatus of controlling uplink transmit power is provided. An estimated path-loss value for each of downlink signals from a control base station and one or more neighboring base stations is calculated. A signal path-loss value by using the calculated plurality of estimated path-loss values is obtained. An open-loop power control parameter by using the signal path-loss value is obtained. Uplink power can be controlled by considering cooperative communication of a plurality of base stations in a multi-cell cooperative radio communication system.