Invention Grant
US08709753B2 Native NAD-dependent GAPDH replaced with NADP-dependent GAPDH plus NADK
有权
天然NAD依赖性GAPDH被NADP依赖性GAPDH加NADK替代
- Patent Title: Native NAD-dependent GAPDH replaced with NADP-dependent GAPDH plus NADK
- Patent Title (中): 天然NAD依赖性GAPDH被NADP依赖性GAPDH加NADK替代
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Application No.: US13680608Application Date: 2012-11-19
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Publication No.: US08709753B2Publication Date: 2014-04-29
- Inventor: Ka-Yiu San , George N. Bennett , Yipeng Wang
- Applicant: William Marsh Rice University
- Applicant Address: US TX Houston
- Assignee: William Marsh Rice University
- Current Assignee: William Marsh Rice University
- Current Assignee Address: US TX Houston
- Agency: Boulware & Valoir
- Main IPC: C12N15/70
- IPC: C12N15/70
Abstract:
This invention is metabolically engineer bacterial strains that provide increased intracellular NADPH availability for the purpose of increasing the yield and productivity of NADPH-dependent compounds. In the invention, native NAD-dependent GAPDH is replaced with NADP-dependent GAPDH plus overexpressed NADK. Uses for the bacteria are also provided.
Public/Granted literature
- US20130084600A1 NATIVE NAD-DEPENDENT GAPDH REPLACED WITH NADP-DEPENDENT GAPDH PLUS NADK Public/Granted day:2013-04-04
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