Various embodiments of the present disclosure provide systems, methods and devices for respiratory support. As one example, a ventilation system is disclosed that includes a computer readable medium including instructions for operating in a hybrid mode. These instructions include measuring patient effort during a spontaneous breath type and deriving a neural inspiratory time from the measurements of patient effort. This neural inspiratory time is then set as the inspiratory for a breath of a mandatory breath type. If new patient effort measurements are received by the ventilator, the neural inspiratory time may be adjusted.