The present subject matter relates to a method and system for pulsed air-actuated micro-droplet on demand jetting, especially for jetting high viscosity liquids. A needle extends from a liquid chamber and terminates in a drop-forming orifice outlet from which micro-droplets are generated. At least two air jets direct a timed pulse of air at the drop-forming orifice outlet of the needle. The pulsed air is synchronized with the formation of a desired volume of liquid at the orifice outlet to extract and propel a micro-droplet at high velocity to a substrate. The air jets are turned on prior to the forming of the desired volume at the orifice outlet of the needle, and turned off after the micro-droplet had been produced.