Embodiments of a medical hand-grip element for injection of a substance from an ampoule, comprise a drive device for driving the ampoule and the injection needle, a delivery device for delivering the medicinal substance out of the ampoule and a coupling device for rotationally fixed coupling of the ampoule with the injection needle and for preventing a relative movement between the ampoule and the injection needle is disclosed. Embodiments of injection systems, injection units, injection needles and handling methods for them are also disclosed in which the risk of injury and contamination for the user is reduced by providing approaches for covering the ends of the cannulas of the injection needles during a number of handling steps.