Invention Grant
- Patent Title: Methods for treating cancer resistant to ErbB therapeutics
- Patent Title (中): 治疗抗ErbB治疗药物的方法
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Application No.: US12450826Application Date: 2008-04-11
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Publication No.: US08715665B2Publication Date: 2014-05-06
- Inventor: Pasi A. Janne , Jeffrey Engelman , Lewis C. Cantley
- Applicant: Pasi A. Janne , Jeffrey Engelman , Lewis C. Cantley
- Applicant Address: US MA Boston US MA Boston US MA Boston
- Assignee: The General Hospital Corporation,Dana Farber Cancer Institute,Beth Israel Deaconess Medical Center
- Current Assignee: The General Hospital Corporation,Dana Farber Cancer Institute,Beth Israel Deaconess Medical Center
- Current Assignee Address: US MA Boston US MA Boston US MA Boston
- Agency: Ropes & Gray LLP
- International Application: PCT/US2008/004804 WO 20080411
- International Announcement: WO2008/127710 WO 20081023
- Main IPC: A61K39/395
- IPC: A61K39/395
Abstract:
Provided herein are methods for treating cancer that is resistant to treatment with an anti-ErbB therapeutic agent and which is associated with an activating MET gene mutation or a MET gene amplification. The methods involve administering to a subject a combination of an anti-ErbB therapeutic and an anti-MET therapeutic. Also provided are methods for reducing ErbB mediated signaling or PI3 kinase mediated signaling in a cancer cell.
Public/Granted literature
- US20120225870A1 METHODS FOR TREATING CANCER RESISTANT TO ERBB THERAPEUTICS Public/Granted day:2012-09-06
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