Invention Grant
US08715668B2 Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 and uses thereof
有权
抗肿瘤坏死因子相关凋亡诱导配体受体DR5的选择性抗体及其用途
- Patent Title: Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 and uses thereof
- Patent Title (中): 抗肿瘤坏死因子相关凋亡诱导配体受体DR5的选择性抗体及其用途
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Application No.: US13621383Application Date: 2012-09-17
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Publication No.: US08715668B2Publication Date: 2014-05-06
- Inventor: Tong Zhou , Kimihisa Ichikawa , Robert P. Kimberly , William J. Koopman
- Applicant: Tong Zhou , Kimihisa Ichikawa , Robert P. Kimberly , William J. Koopman
- Applicant Address: US AL Birmingham
- Assignee: The UAB Research Foundation
- Current Assignee: The UAB Research Foundation
- Current Assignee Address: US AL Birmingham
- Agency: Kilpatrick, Townsend & Stockton LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K16/30
Abstract:
An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
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